Mite faeces are a major source of house dust allergens

  title={Mite faeces are a major source of house dust allergens},
  author={E. Tovey and M. Chapman and T. Platts-Mills},
The association between house dust allergy and asthma has long been recognized, and it has been demonstrated that a major allergen in house dust is related to the presence of mites of the genus Dermatophagoides1. Using extracts of mite culture for skin testing, as many as 10% of the population and up to 90% of allergic asthmatics give positive immediate reactions2. Although mites may occasionally become airborne during bed-making3, it has also been demonstrated that they ‘secrete or excrete… Expand
Allergy to House Dust Mites and Asthma
House Dust mites are the most frequently encountered aeroallergens. Their role in sensitizing asthmatic patients was first reported in 1921, and the association of house dust mite allergy, asthma,Expand
House dust mite exposure as a cause of asthma
The infonnation from diverse studies which when combined strongly suggests that exposure to allergens is an important cause of asthma are reviewed, focusing on house dust mite allergens because it is the most complete. Expand
The distribution of dust mite allergen in the houses of patients with asthma.
The results suggested that natural exposure to this dust allergen allows occasional fecal particles to enter the lungs and that these particles contain very concentrated allerGEN. Expand
Characterization and Immunobiology of House Dust Mite Allergens
While some estimate of the importance of allergens can be obtained from IgE binding, few analyses of T-cell responses have been made and these regulate both the development of, and the protection from sensitization. Expand
Guanine dosage in house dust samples and quantification of mite allergens.
Major house dust mite allergens have been purified and it is now possible to measure these allergens accurately in house dust or air samples and to develop a radioimmunoassay (RIA) for antigen PI measurement. Expand
Mite allergen (Der p 1) is not only carried on mite feces.
The sources of Der p 1 aeroallergen are investigated by using a new technique, which enables individual particles containing allergen to be visualized, and it is proposed that a low proportion of these large fecal particles would enter the lower airways, and the effects of high localAllergen concentrations from each particle, on chronic exposure, might provide sufficient stimulus to maintain or produce hyperreactivity. Expand
The allergenic specificities of the house dust mite.
Component resolved diagnosis is a newly developing procedure that uses allergen arrays to provide a diagnostic format to differentiate between cross-reacting allergens and to identify the optimal formulation of allergens for different patients. Expand
House dust mite in different altitudes of Grisons.
These studies suggested that the relevant form of mite allergens was almost certainly the fecal pellet, and it was shown that the allergen accumulates in mite culture as fecal pellets and also becomes airborne in form of fecAL pellets. Expand
Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.
Interestingly, it is found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor aller gen for patientssuffering from respiratory forms of HDM allergy. Expand
The role of domestic allergens.
Although sensitization of asthmatics reflects the concentration of allergens in their houses, these measurements of exposure do not accurately predict severity of symptoms, and diesel particulates, ozone, beta 2-agonists, endotoxin and rhinovirus infection have each been shown to enhance the inflammatory response to inhaled allergens. Expand


Clinical significance of skin reactions to mite extracts in children with asthma.
Allergy to house-dust mites, particularly D. pteronyssinus, is of considerable importance in childhood asthma, and further study of the ecology and control of the mites in dust is desirable. Expand
Allergens and the Genetics of Allergy
It has been shown that, other than a tendency for allergens to be at the lower end of the molecular weight spectrum of antigens, there is no general chemical feature that characterizes allergens as a subpopulation of ants. Expand
Mites in Bedroom Air
VOORHORST et al.1 found that, among the many constituents of house dust causing allergic reactions of the respiratory tract (rhinitis and asthma) in people sensitive to house dust, a hitherto littleExpand
The respiratory retention of bacterial aerosols: experiments with radioactive spores.
The distribution of inhaled bacterial aerosols has been studied in guinea-pigs, monkeys and mice, using Bacillus subtilis spores labelled with radiophosphorus, and the subsequent fate of the retained particles accords with what is known about ciliary removal. Expand