Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes.

@article{Dai2011MiteAI,
  title={Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes.},
  author={Xiuju Dai and Koji Sayama and Mikiko Tohyama and Yuji Shirakata and Yasushi Hanakawa and Sho Tokumaru and Lujun Yang and Satoshi Hirakawa and Koji Hashimoto},
  journal={The Journal of allergy and clinical immunology},
  year={2011},
  volume={127 3},
  pages={806-14.e1-4}
}
BACKGROUND Atopic dermatitis (AD) is a chronic inflammatory skin disorder caused by multiple factors. Among them, house dust mite (HDM) allergens are important in the development of AD. In airway allergy, HDM allergens activate innate immunity. However, information regarding the activation of innate immunity by HDM allergens in the skin is limited. OBJECTIVES The inflammasome is a key regulator of pathogen recognition and inflammation. We investigated whether HDM allergens activate the… CONTINUE READING