Mission impossible: IGF-1 and PTEN specifically "Akt"ing on cardiac L-type Ca2+ channels.


The complex functional properties of cardiomyocytes are precisely regulated, oftentimes with millisecond precision. There are a multitude of signaling cascades and associated molecules that participate in this regulation. Insulin-like growth factor-1 (IGF-1), IGF receptors, phosphoinositides, phosphatidylinositol 3-kinase (PI3K), Akt or phosphokinase B (PKB… (More)