Missing heritability of complex diseases: case solved?

@article{Gnin2019MissingHO,
  title={Missing heritability of complex diseases: case solved?},
  author={Emmanuelle G{\'e}nin},
  journal={Human Genetics},
  year={2019},
  pages={1-11}
}
About 10 years ago, after the first large-scale genome-wide association studies (GWAS) were conducted to find genes associated with common complex diseases, investigators were surprised to find that the amount of heritability explained by the significant hits was very low for almost all the studied traits. Indeed, when compared to heritability estimates expected from the observed trait concordance within families, the heritability explained by the associated variants was always much smaller… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 89 REFERENCES

Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2018

Missing compared to what? Revisiting heritability, genes and culture

  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2018
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