Missing data in confirmatory clinical trials.

  title={Missing data in confirmatory clinical trials.},
  author={Paul Flyer and Joseph Hirman},
  journal={Journal of biopharmaceutical statistics},
  volume={19 6},
Missing data for key efficacy and safety endpoints in clinical trials have the potential to undermine the scientific integrity of the study and prevent definitive conclusions regarding the safety and efficacy of an experimental product. Much of the missing data is the result of poor protocol design and a lack of agreement in the scientific community regarding the collection of study data after treatment discontinuation instead of an inability to collect the data. Rather than dealing with the… CONTINUE READING

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