Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity

  title={Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity},
  author={Angelisa Frasca and Marlien Wilhelmina Aalbers and Federica Frigerio and Fabio Fiordaliso and Annamaria Vezzani},
  journal={Neurobiology of Disease},
Pharmacological blockade of NR2B-containing N-methyl-d-aspartate receptors (NMDARs) during epileptogenesis reduces neurodegeneration provoked in the rodent hippocampus by status epilepticus. The functional consequences of NMDAR activation are crucially influenced by their synaptic vs extrasynaptic localization, and both NMDAR function and localization are dependent on the presence of the NR2B subunit and its phosphorylation state. We investigated whether changes in NR2B subunit phosphorylation… CONTINUE READING


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