Mispaired rNMPs in DNA are mutagenic and are targets of mismatch repair and RNases H

@article{Shen2011MispairedRI,
  title={Mispaired rNMPs in DNA are mutagenic and are targets of mismatch repair and RNases H},
  author={Ying Shen and Kyung Duk Koh and Bernard Weiss and Francesca Storici},
  journal={Nature Structural &Molecular Biology},
  year={2011},
  volume={19},
  pages={98-104}
}
Numerous studies have shown that ribonucleoside monophosphates (rNMPs) are probably abundant among all nonstandard nucleotides occurring in genomic DNA. Therefore, it is important to understand to what extent rNMPs may alter genome integrity and what factors affect their stability. We developed oligonucleotide-driven gene correction assays in Escherichia coli and Saccharomyces cerevisiae to show that mispaired rNMPs embedded into genomic DNA, if not removed, serve as templates for DNA synthesis… CONTINUE READING
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Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases.

Proceedings of the National Academy of Sciences of the United States of America • 2010

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