Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.

@article{Draviam2006MisorientationAR,
  title={Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.},
  author={Viji M. Draviam and Irene Shapiro and Billy Aldridge and Peter K. Sorger},
  journal={The EMBO journal},
  year={2006},
  volume={25 12},
  pages={
          2814-27
        }
}
The correct formation of stable but dynamic links between chromosomes and spindle microtubules (MTs) is essential for accurate chromosome segregation. However, the molecular mechanisms by which kinetochores bind MTs and checkpoints monitor this binding remain poorly understood. In this paper, we analyze the functions of six kinetochore-bound MT-associated proteins (kMAPs) using RNAi, live-cell microscopy and quantitative image analysis. We find that RNAi-mediated depletion of two kMAPs, the… CONTINUE READING

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