Misoprostol but not antacid prevents endotoxin-induced gastric mucosal injury

@article{Mahatma2005MisoprostolBN,
  title={Misoprostol but not antacid prevents endotoxin-induced gastric mucosal injury},
  author={M Mahatma and Naurang M. Agrawal and Esam Z. Dajani and Steve Nelson and C Nakamura and John Sitton},
  journal={Digestive Diseases and Sciences},
  year={2005},
  volume={36},
  pages={1562-1568}
}
Many of the complications of septic shock are believed to be a consequence of elevated circulating levels of tumor necrosis factor (TNF), which is an important mediator of tissue injury. Prostaglandins (PGs) of the E series have recently been reported to inhibit TNF productionin vitro. We investigated thein vivo effect of misoprostol, a PGE1 analog, on endotoxin-induced gastric mucosal injury and TNF production. For the gastric mucosal injury studies, groups of animals were pretreated with… 
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