Misoprostol but not antacid prevents endotoxin-induced gastric mucosal injury

  title={Misoprostol but not antacid prevents endotoxin-induced gastric mucosal injury},
  author={M Mahatma and Naurang M. Agrawal and Esam Z. Dajani and Steve Nelson and C Nakamura and John Sitton},
  journal={Digestive Diseases and Sciences},
Many of the complications of septic shock are believed to be a consequence of elevated circulating levels of tumor necrosis factor (TNF), which is an important mediator of tissue injury. Prostaglandins (PGs) of the E series have recently been reported to inhibit TNF productionin vitro. We investigated thein vivo effect of misoprostol, a PGE1 analog, on endotoxin-induced gastric mucosal injury and TNF production. For the gastric mucosal injury studies, groups of animals were pretreated with… 
Misoprostol Inhibits Lipopolysaccharide-Induced Pro-inflammatory Cytokine Production by Equine Leukocytes
Results indicate that misoprostol exerts anti-inflammatory effects on equine leukocytes when applied before or after a pro-inflammatory stimulus, and these effects were cytokine-specific and sometimes differed at the mRNA and protein levels.
Effects of the Prostaglandin Analogue Misoprostol on TNF-alpha Release by Activated Equine Leukocytes.
The results presented in this study show that addition of LPS to equine leukocytes induced TNF-α secretion and misoprostol effectively blunted this response, suggesting misop frostol may be useful as an immunomodulator of inflammatory cytokine production in SIRS/sepsis.
A randomized controlled trial of misoprostol monotherapy for canine atopic dermatitis: effects on dermal cellularity and cutaneous tumour necrosis factor-alpha.
The modest efficacy of misoprostol for treatment of canine AD is confirmed and its mild anti-allergic effects are suggested to be associated with either inhibition of inflammatory cell emigration or TNFalpha production.
A randomized, double-blind, placebo-controlled trial of misoprostol for oral mucositis secondary to high-dose chemotherapy
This study did not find a beneficial effect of a misoprostol rinse in mucositis secondary to high-dose chemotherapy, and the small sample size limits the strength of this conclusion.
Relationship between the 308GA polymorphism of the tumor necrosis factor alpha gene and acute or chronic pancreatitis: a meta-analysis
Assessment of whether a relationship exists between G308A polymorphism of TNF-α gene and acute or chronic pancreatitis using meta-analysis finds no relationship exists.


Gastric mucosal damage in sepsis--effects of pretreatment with a synthetic prostaglandin E1 analogue.
The protective effect of misoprostol was not dependent on increased gastric mucosal blood flow, nor was it mediated through effects on mucosal nucleic acid concentrations or ratio, as well as the haemodynamic response to bacteria.
Overview of the mucosal protective effects of misoprostol in man.
Shock and tissue injury induced by recombinant human cachectin.
It appears that a single protein mediator (cachectin) is capable of inducing many of the deleterious effects of endotoxin.
Effects of misoprostol on gastric acid and mucus secretion in man
Mucus secretion increased by 37%, 82%, and 95% during the basal period following misoprostol doses of 200, 400, and 800 μg, respectively, and this mucogenic effect may be important in the mucosal protective action of misop frostol and its antiulcer efficacy in man.
Misoprostol versus antacid titration for preventing stress ulcers in postoperative surgical ICU patients.
It is concluded that fixed-dose misoprostol is as effective as intensive antacid titration in preventing stress ulcers and bleeding in surgical ICU patients.
Inhibition of nocturnal gastric secretion in normal human volunteers by misoprostol: a synthetic prostaglandin E1 methyl ester analog.
The present studies indicate that misoprostol is a promising therapeutic agent for the treatment of peptic ulcer.
Compartmentalization of intraalveolar and systemic lipopolysaccharide-induced tumor necrosis factor and the pulmonary inflammatory response.
Levels of TNF both in bronchoalveolar lavage fluid and associated with alveolar macrophages increased significantly from near nondetectable levels in control animals, and increases in TNF levels were confined to the LPS-challenged compartment.