Misoprostol administration prior to intrauterine contraceptive device insertion: a systematic review and meta-analysis of randomised controlled trials

@article{Tassi2020MisoprostolAP,
  title={Misoprostol administration prior to intrauterine contraceptive device insertion: a systematic review and meta-analysis of randomised controlled trials},
  author={Alice Tassi and Nadia Parisi and Ambrogio Pietro Londero},
  journal={The European Journal of Contraception \& Reproductive Health Care},
  year={2020},
  volume={25},
  pages={76 - 86}
}
Abstract Objectives: Misoprostol has been used before intrauterine contraceptive device (IUCD) insertion to prime the cervical os. As the literature about this topic is controversial, we aimed to evaluate IUCD insertion failure, women’s pain perception, use of cervical dilators and prevalence of side effects following the administration of misoprostol. Methods: Trials published in MEDLINE, Scopus, the Cochrane Library and ClinicalTrials.gov were searched (last search on 23 October 2019). The… Expand
Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery.
TLDR
Using of misoprostol to facilitate IUD insertion in women with tight cervix, has no role in pain reduction or increase the ease of IUD Insertion, although results with misOProstol are superior to placebo, but the different did not reach statistical significance. Expand
Vaginal dinoprostone versus placebo for pain relief during intrauterine device insertion: a systematic review and meta-analysis of randomized controlled trials
TLDR
This first ever meta-analysis advocates that dinoprostone is safe, effective, and yields favorable analgesic outcomes during IUD insertion. Expand
Comparative Efficacy of Vaginal Misoprostol Versus Vaginal Dinoprostone Administered Three Hours Prior To Copper T380A Intrauterine Device Insertion in Nulliparous Women: A Randomized Controlled Trial.
TLDR
Premedication with vaginal misoprostol or dinoprostone effectively lowered pain during copper IUD insertion, and clinicians found the procedure easier, and women were more satisfied with IUD Insertion. Expand
Vaginal dinoprostone versus placebo for pain relief during intrauterine device insertion: a systematic review and meta-analysis of randomised controlled trials
  • A. Abu-Zaid, M. Alshahrani, +10 authors S. Baradwan
  • Medicine
  • The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2021
TLDR
This first ever meta-analysis advocates that dinoprostone compared with placebo is safe, effective, and yields favourable analgesic outcomes during IUD insertion. Expand
Hormone Replacement Therapy in Endometrial Cancer Survivors: A Meta-Analysis
TLDR
Supporting evidence is based mainly upon observational studies, evidence of no increased risk or even decreased risk was generally found, apart from in Black American women where a significantly increased recurrence risk was evident. Expand

References

SHOWING 1-10 OF 52 REFERENCES
Effect of vaginal administration of misoprostol before intrauterine contraceptive insertion following previous insertion failure: a double blind RCT.
TLDR
Pretreatment with intravaginal administration of 200 mcg of misoprostol after IUC insertion failure 10 and 4 h before the second attempt of IUC placement was significantly better than placebo at facilitating the insertion of an IUC. Expand
Vaginal misoprostol prior to insertion of an intrauterine device: an RCT.
TLDR
The study showed no benefit for use of misoprostol prior to IUD insertion, and there is a tendency of possible harm regarding side-effects, therefore, the study would not recommend standard pretreatment with misop frostol. Expand
Misoprostol prior to inserting an intrauterine device in nulligravidas: a randomized clinical trial.
TLDR
The present study shows that the benefits of misoprostol use prior to IUD insertion include facilitating insertion and reducing pain during the procedure; therefore, weighing up the benefits encountered against the only negative side effect (cramps prior to insertion), these results suggest that misop frostol use should become standard practice to facilitate Iud insertion in nulligravidas. Expand
Benefits of vaginal misoprostol prior to IUD insertion in women with previous caesarean delivery: a randomised controlled trial
  • A. Maged, G. Youssef, +5 authors A. Ogila
  • Medicine
  • The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2018
TLDR
The use of misoprostol before IUD insertion is associated with less painful and easier placement, and it is shown that women with previous Caesarean delivery who receive this drug are more likely to receive an IUD. Expand
Vaginal misoprostol before copper IUD insertion after previous insertion failure: a double-blind, placebo-controlled, parallel-group, randomised clinical trial
TLDR
Vaginal misoprostol before IUD insertion in parous women with previous insertion failure increased the rate of successful insertion, particularly in women withPrevious caesarean delivery. Expand
Cervical priming with sublingual misoprostol prior to insertion of an intrauterine device in nulliparous women: a randomized controlled trial.
TLDR
Misoprostol facilitates insertion of an IUD, and reduces the number of difficult and failed attempts of insertions in women with a narrow cervical canal. Expand
Sublingual misoprostol prior to insertion of a T380A intrauterine device in women with no previous vaginal delivery
  • Z. M. Ibrahim, W. A. Sayed Ahmed
  • Medicine
  • The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2013
TLDR
Sublingual administration of misoprostol one hour before intrauterine device (IUD) insertion in parous women with no previous vaginal delivery does not facilitate the procedure and may cause undesirable side effects. Expand
Vaginal misoprostol prior to intrauterine device insertion in women delivered only by elective cesarean section: a randomized double-blind clinical trial.
TLDR
The use of vaginal misoprostol vaginally prior to IUD insertion in women who had never delivered vaginally before may increase the ease and success of insertion and reduce the pain felt by women during the procedure. Expand
Effects of prophylactic misoprostol administration prior to intrauterine device insertion in nulliparous women.
TLDR
Prophylactic misoprostol prior to IUD placement in nulliparous women did not reduce patient perceived pain, but it did appear to increase preinsertion side effects. Expand
Inserting intrauterine devices in nulliparous women : is misoprostol beneficial ? A registered clinical trial
Background: To determine if misoprostol use prior to intrauterine device (IUD) insertion decreases pain and eases insertion in nulliparous women. Study Design: Nulliparous women requesting IUDs forExpand
...
1
2
3
4
5
...