Misoprostol With or Without Letrozole Pretreatment for Termination of Pregnancy: A Randomized Controlled Trial

  title={Misoprostol With or Without Letrozole Pretreatment for Termination of Pregnancy: A Randomized Controlled Trial},
  author={Vivian Chi Yan Lee and Ernest Hung Yu Ng and William S B Yeung and Pak-chung Ho},
  journal={Obstetrics \& Gynecology},
OBJECTIVE: To compare the success rate and side effects of letrozole and misoprostol versus misoprostol alone for medical termination of early pregnancy. METHODS: Patients requesting termination of pregnancy up to 63 days of gestation were randomized into two groups. The letrozole group received letrozole 10 mg daily for 3 days followed by 800 micrograms of vaginal misoprostol, while the placebo group received placebo for 3 days followed by the same dosage of misoprostol. The complete abortion… 

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