Misoprostol Vaginal Insert and Time to Vaginal Delivery: A Randomized Controlled Trial

@article{Wing2013MisoprostolVI,
  title={Misoprostol Vaginal Insert and Time to Vaginal Delivery: A Randomized Controlled Trial},
  author={Deborah A. Wing and Raymond Brown and Lauren A. Plante and Hugh S. Miller and Olof Rugarn and Barbara L. Powers},
  journal={Obstetrics \& Gynecology},
  year={2013},
  volume={122},
  pages={201–209}
}
OBJECTIVE: To compare the efficacy and safety of a 200-microgram misoprostol vaginal insert with a 10-mg dinoprostone vaginal insert for reducing the time to vaginal delivery. METHODS: In a phase III, double-blind, multicenter study, women being induced with a modified Bishop score of 4 or less were randomly assigned to receive either a 200-microgram misoprostol vaginal insert or a 10-mg dinoprostone vaginal insert. Coprimary end points were time to vaginal delivery and rate of cesarean… Expand
Misoprostol vaginal insert versus misoprostol vaginal tablets for the induction of labour: a cohort study
TLDR
MVI achieves a more vaginal delivery rate within 24 h and Tachysystole events compared to MVT, however, no differences in caesarean section, operative vaginal delivery, and neonatal outcomes are reported. Expand
Misoprostol vaginal insert versus dinoprostone vaginal insert: A comparison of labour and delivery outcomes.
TLDR
MVI significantly reduces the induction to delivery interval, has a similar caesarean section rate and neonatal outcomes, when compared with DVI, a vaginal insert used in the induction of labour at NHS Fife. Expand
A critical appraisal of the misoprostol removable, controlled-release vaginal delivery system of labor induction
TLDR
Current data suggest that the 100 μg MVI would provide the best balance between efficacy and safety, especially in high-risk situations needing induction of labor. Expand
Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
TLDR
There was no significant difference in effectiveness of the three groups of induction at randomization, andound newborn acidemia, though infrequent, occurred only with low dose vaginal misoprostol. Expand
Initial clinical experience with a misoprostol vaginal insert in comparison with a dinoprostone insert for inducing labor.
TLDR
The groups thus had similar results for rates of vaginal delivery within 24h, cesarean delivery and fetal outcomes, and the misoprostol group had lower modified Bishop scores, higher BMIs, and a higher rate of fetal scalp blood testing. Expand
Efficacy and safety of misoprostol vaginal insert vs. oral misoprostol for induction of labor
TLDR
Time to delivery was significantly shorter in the MVI group with a higher rate of vaginal deliveries within the first 24 h, however, patients needed more opioids for pain relief during induction with MVI, and there was no difference in neonatal outcomes. Expand
A comparison of misoprostol vaginal insert and misoprostol vaginal tablets for induction of labor in nulliparous women: a retrospective cohort study
TLDR
In a setting of routine obstetric care, MVI seems to be a more efficient labor induction agent than MVT, and with a lower CS rate and no increase in adverse infant outcomes. Expand
The misoprostol vaginal insert compared with oral misoprostol for labor induction in term pregnancies: a pair-matched case-control study
TLDR
The MVI compared with OM significantly shortened the time from application to delivery at the expense of a higher cesarean section rate and negative effects on neonatal outcomes. Expand
Clinical experience with misoprostol vaginal insert for induction of labor: a prospective clinical observational study
TLDR
When clinically indicated, MVI was efficient and safe for induction of labor in women with an unfavorable cervix, however, women should be counseled regarding the risk of uterine tachysystole prior to labor induction with MVI. Expand
Standard and adjusted criteria for the use of the misoprostol vaginal insert for labor induction: a comparative cohort study
TLDR
The time from induction to delivery with MVI was similar when using standard criteria of up to 24 h of exposure vs. adjusted criteria ofup to 10 h of Exposure, and although the threshold for statistical significance for cesarean section was not attained, there is nonetheless a considerable difference between the MVI-24 and M VI-10 groups. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Misoprostol Vaginal Insert Compared With Dinoprostone Vaginal Insert: A Randomized Controlled Trial
  • D. Wing
  • Medicine
  • Obstetrics and gynecology
  • 2008
TLDR
The misoprostol vaginal insert 100 and the dinoprostone vaginal insert had similar median time intervals to vaginal delivery, whereas the misopral vaginal insert 50 had a significantly longer time to vaginal Delivery. Expand
Pharmacokinetic Profiles of Controlled‐Release Hydrogel Polymer Vaginal Inserts Containing Misoprostol
TLDR
The pharmacokinetic profiles of these vaginal inserts and orally administered misoprostol were investigated to address uncertainty regarding the correct dose and the difficulty in removing the product when there is an adverse event. Expand
Vaginal misoprostol for cervical ripening and induction of labour.
TLDR
Vaginal misoprostol labour induction was associated with less epidural analgesia use, fewer failures to achieve vaginal delivery within 24 hours and more uterine hyperstimulation. Expand
Vaginal misoprostol for cervical ripening and induction of labour.
TLDR
Vaginal misoprostol in doses above 25 mcg four-hourly was more effective than conventional methods of labour induction, but with more uterine hyperstimulation, and lower doses were similar to conventional methods in effectiveness and risks. Expand
Women's perceptions, expectations and satisfaction with induced labour--a questionnaire-based study.
TLDR
Labour that is artificially induced does result in lower satisfaction rates as compared to that following spontaneous onset, and there is a need to improve the information provided to women undergoing labour induction, to counter unrealistic expectations and thereby improve satisfaction. Expand
Management of Intrapartum Fetal Heart Rate Tracings
TLDR
This second Practice Bulletin on intrapartum FHR tracings reviews the management of heart rate patterns based on the three-tiered classification system. Expand
THE AMERICAN COLLEGE OF OBSTETRICIANS AND GYNECOLOGISTS
Committee on Practice Bulletins—Obstetrics. This Practice Bulletin was developed by the Committee on Practice Bulletins—Obstetrics with the assistance of Charles Lockwood, MD, and George Wendel, MD.Expand
Births: final data for 2009.
  • Joyce A. Martin, B. Hamilton, +4 authors Elizabeth C Wilson
  • Medicine
  • National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System
  • 2011
TLDR
This report presents 2009 data on U.S. births according to a wide variety of characteristics, including age, live-birth order, race and Hispanic origin, marital status, hypertension during pregnancy, attendant at birth, method of delivery, and infant characteristics. Expand
Misoprostol Vaginal Insert for Successful Labor Induction: A Randomized Controlled Trial
...
1
2
3
...