Misonidazole protects mouse tumour and normal tissues from the toxicity of oral CCNU.


Because the nitrosourea CCNU is given exclusively by the oral route in man, we have carried out studies in mice on the antitumour activity, acute toxicity and pharmacokinetics of oral CCNU, either alone or in combination with the chemosensitizer misonidazole. In both plasma and KHT tumour the peak concentration and "early" AUC for total nitrosoureas were… (More)
DOI: 10.1038/bjc.1985.12


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