Misonidazole increases the toxicity of BCNU for hypoxic cells.

Abstract

Misonidazole (MISO) increased the toxicity of BCNU for hypoxic Chinese Hamster Ovary (CHO) cells in vitro, but had no effect on aerobic toxicity of BCNU. Survival was reduced by up to 10(-3) with an exposure to MISO (ImM x 4 hr) that had no direct toxicity for hypoxic cells. Preincubation of cells with MISO under hypoxic conditions followed by exposure to… (More)

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@article{Tannock1982MisonidazoleIT, title={Misonidazole increases the toxicity of BCNU for hypoxic cells.}, author={Ian F. Tannock and Patricia Guttman}, journal={International journal of radiation oncology, biology, physics}, year={1982}, volume={8 3-4}, pages={663-6} }