Misonidazole and other hypoxia markers: metabolism and applications.

  title={Misonidazole and other hypoxia markers: metabolism and applications.},
  author={Allan Franko},
  journal={International journal of radiation oncology, biology, physics},
  volume={12 7},
  • Allan Franko
  • Published 1986 in
    International journal of radiation oncology…
A substantial effort is being devoted to developing markers for hypoxia in tumors. Most of the work to date has been performed on misonidazole (MISO), which is selectively metabolized by hypoxic cells to reactive products that bind covalently to cellular constituents. This paper attempts to review the metabolism of MISO as it relates to binding, to summarize several of the properties of the binding of MISO to cells and tissues which appear to be directly relevant to the characteristics of the… CONTINUE READING

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