Mismatch repair regulates homologous recombination, but has little influence on antigenic variation, in Trypanosoma brucei.

@article{Bell2003MismatchRR,
  title={Mismatch repair regulates homologous recombination, but has little influence on antigenic variation, in Trypanosoma brucei.},
  author={Joanna S Bell and Richard McCulloch},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 46},
  pages={45182-8}
}
Antigenic variation is critical in the life of the African trypanosome, as it allows the parasite to survive in the face of host immunity and enhance its transmission to other hosts. Much of trypanosome antigenic variation uses homologous recombination of variant surface glycoprotein (VSG)-encoding genes into specialized transcription sites, but little is known about the processes that regulate it. Here we describe the effects on VSG switching when two central mismatch repair genes, MSH2 and… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…