Mismatch repair proteins: key regulators of genetic recombination

@article{Surtees2004MismatchRP,
  title={Mismatch repair proteins: key regulators of genetic recombination},
  author={J. Surtees and J. L. Argueso and E. Alani},
  journal={Cytogenetic and Genome Research},
  year={2004},
  volume={107},
  pages={146 - 159}
}
Mismatch repair (MMR) systems are central to maintaining genome stability in prokaryotes and eukaryotes. MMR proteins play a fundamental role in avoiding mutations, primarily by removing misincorporation errors that occur during DNA replication. MMR proteins also act during genetic recombination in steps that include repairing mismatches in heteroduplex DNA, modulating meiotic crossover control, removing 3′ non-homologous tails during double-strand break repair, and preventing recombination… Expand
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GOLDFARB and ALANI 1 Distinct roles for the Saccharomyces cerevisiae mismatch repair proteins in heteroduplex rejection , mismatch repair , and non-homologous tail removal
The Saccharomyces cerevisiae mismatch repair (MMR) protein MSH6 and the SGS1 helicase were recently shown to play similarly important roles in preventing recombination between divergent DNA sequencesExpand
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References

SHOWING 1-10 OF 168 REFERENCES
Mitotic crossovers between diverged sequences are regulated by mismatch repair proteins in Saccaromyces cerevisiae
TLDR
It is found that the apparent antirecombination effects of mismatch repair proteins in mitosis are related to the degree of substrate divergence, which has implications for genome stability and general mechanisms of recombination in eukaryotes. Expand
Mismatch Repair Proteins Regulate Heteroduplex Formation during Mitotic Recombination in Yeast
TLDR
The products of mitotic recombination between 94%-identical substrates are sequenced in order to map gene conversion tracts in wild-type versus MMR-defective yeast strains and indicate that most recombination occurs via sister chromatid conversion. Expand
Regulation of mitotic homeologous recombination in yeast. Functions of mismatch repair and nucleotide excision repair genes.
TLDR
The Saccharomyces cerevisiae homologs of the bacterial mismatch repair proteins MutS and MutL correct replication errors and prevent recombination between homeologous (nonidentical) sequences are studied to show that Mlh1p and Msh6p have important antirecombination roles. Expand
The role of the mismatch repair machinery in regulating mitotic and meiotic recombination between diverged sequences in yeast.
TLDR
The recombination rate data indicate that sequence divergence impacts mitotic and meiotic recombination similarly, although subtle differences are evident. Expand
Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast.
TLDR
It is found that a single mismatch is sufficient to inhibit recombination between otherwise identical sequences, and that this inhibition is dependent on the mismatch repair system. Expand
Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins
TLDR
The ratio of gene-conversion to PMS events reflects the efficiency of DNA repair, and it is found that the repair of 26-base loops involves Msh2 (a DNA-mismatch repair protein) and Rad1 (a protein required for nucleotide-excision repair). Expand
Control of large chromosomal duplications in Escherichia coli by the mismatch repair system.
TLDR
It is concluded that mismatch repair proteins serve as general controllers of the fidelity of genetic inheritance, acting to suppress chromosomal rearrangements as well as point mutations. Expand
Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae
TLDR
In a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1, it is found that this activity does not depend on genes required for nucleotide excision repair and thus differs from the short‐patch mismatch repair described in Schizosaccharomyces pombe. Expand
Highly mismatched molecules resembling recombination intermediates efficiently transform mismatch repair proficient Escherichia coli.
TLDR
It is proposed that the prevention of recombination between highly diverged DNAs may be at a step earlier than heteroduplex formation, based on results with E. coli and yeast. Expand
Mammalian DNA mismatch repair.
TLDR
Genetic studies in cultured mammalian cells and mice are proving to be instrumental in defining the relationship between the functions of MMR in mutation and tumor avoidance, and approaches have raised awareness that MMR homologs contribute to DNA damage surveillance, transcription-coupled repair, and recombinogenic and meiotic processes. Expand
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