Mismatch repair protein deficiency compromises cisplatin-induced apoptotic signaling.

@article{Topping2009MismatchRP,
  title={Mismatch repair protein deficiency compromises cisplatin-induced apoptotic signaling.},
  author={Ryan P Topping and John C Wilkinson and Karin Drotschmann Scarpinato},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 21},
  pages={
          14029-39
        }
}
Mismatch repair (MMR) proteins participate in cytotoxicity induced by certain DNA damage-inducing agents, including cisplatin (cis-diamminedichloroplatinum(II), CDDP), a cancer chemotherapeutic drug utilized clinically to treat a variety of malignancies. MMR proteins have been demonstrated to bind to CDDP-DNA adducts and initiate MMR protein-dependent cell death in cells treated with CDDP; however, the molecular events underlying this death remain unclear. As MMR proteins have been suggested to… CONTINUE READING

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