Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA.

@article{Mojas2007MismatchRP,
  title={Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA.},
  author={Nina Mojas and Massimo Lopes and Josef Jiricny},
  journal={Genes & development},
  year={2007},
  volume={21 24},
  pages={3342-55}
}
O(6)-Methylguanine ((Me)G) is a highly cytotoxic DNA modification generated by S(N)1-type methylating agents. Despite numerous studies implicating DNA replication, mismatch repair (MMR), and homologous recombination (HR) in (Me)G toxicity, its mode of action has remained elusive. We studied the molecular transactions in the DNA of yeast and mammalian cells treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Although replication fork progression was unaffected in the first cell cycle after… CONTINUE READING

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We studied the molecular transactions in the DNA of yeast and mammalian cells treated with N - methyl - N'-nitro - N - nitrosoguanidine ( MNNG ) .
We studied the molecular transactions in the DNA of yeast and mammalian cells treated with N - methyl - N'-nitro - N - nitrosoguanidine ( MNNG ) .
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