Mismatch repair deficiency may affect clinical outcome through immune response activation in metastatic gastric cancer patients receiving first-line chemotherapy

@article{Giampieri2016MismatchRD,
  title={Mismatch repair deficiency may affect clinical outcome through immune response activation in metastatic gastric cancer patients receiving first-line chemotherapy},
  author={Riccardo Giampieri and Elena Maccaroni and Alessandra Mandolesi and Michela Del Prete and Kalliopi Andrikou and Luca Faloppi and Alessandro Bittoni and Maristella Bianconi and Marina Scarpelli and Raffaella Bracci and Mario Scartozzi and Stefano Cascinu},
  journal={Gastric Cancer},
  year={2016},
  volume={20},
  pages={156-163}
}
IntroductionThe microsatellite-instable gastric cancer subtype, because of its supposed high antigenic potential, is a promising candidate for immunotherapy. We analyzed if the presence of a defective mismatch repair (MMR) system is associated with other markers of immune response and their relationship with outcome in advanced gastric cancer patients.MethodsWe analyzed the relationship between clinical outcome and MMR status, the presence of tumor-infiltrating lymphocytes (TIL), lymphocytosis… CONTINUE READING
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From Tumor Immunology to Immunotherapy in Gastric and Esophageal Cancer

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Optimal management of resected gastric cancer

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