Mismatch repair, G(2)/M cell cycle arrest and lethality after DNA damage.

@article{Aquilina1999MismatchRG,
  title={Mismatch repair, G(2)/M cell cycle arrest and lethality after DNA damage.},
  author={Gabriele Aquilina and Marco Crescenzi and Margherita Bignami},
  journal={Carcinogenesis},
  year={1999},
  volume={20 12},
  pages={2317-26}
}
The role of the mismatch repair pathway in DNA replication is well defined but its involvement in processing DNA damage induced by chemical or physical agents is less clear. DNA repair and cell cycle control are tightly linked and it has been suggested that mismatch repair is necessary to activate the G(2)/M checkpoint in the presence of certain types of DNA damage. We investigated the proposed role for mismatch repair (MMR) in activation of the G(2)/M checkpoint following exposure to DNA… CONTINUE READING
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