Mismatch Negativity: Clinical and Other Applications

@article{Ntnen2000MismatchNC,
  title={Mismatch Negativity: Clinical and Other Applications},
  author={Risto N{\"a}{\"a}t{\"a}nen and Carles Escera},
  journal={Audiology and Neurotology},
  year={2000},
  volume={5},
  pages={105 - 110}
}
The perspectives of application of the mismatch negativity (MMN), generated by the brain’s automatic response to change in auditory stimulation, are discussed. In light of the fact that the MMN (and its magnetic equivalent MMNm) currently provides the only objective measure of the accuracy of the central auditory function, these perspectives appear very promising. The MMN can be measured in the absence of attention and task requirements, which makes it particularly suitable for testing… Expand
Mismatch negativity: clinical research and possible applications.
  • R. Näätänen
  • Psychology, Medicine
  • International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 2003
TLDR
The MMN (and its magnetic equivalent MMNm) currently provide the only objective measure of auditory discrimination and sensory memory and can be registered in the absence of attention and with no task requirements, which makes it particularly suitable for studying different clinical populations and infants. Expand
The mismatch negativity in cognitive and clinical neuroscience: Theoretical and methodological considerations
TLDR
Some of the essential MMN findings in probing sound discrimination, memory, and their deficits are introduced and issues which need to be taken into account in MMN investigations as well as new improved recording paradigms are discussed. Expand
The mismatch negativity (MMN) response to complex tones and spoken words in individuals with aphasia
Background: The mismatch negativity (MMN) is a fronto-centrally distributed event-related potential (ERP) that is elicited by any discriminable auditory change. It is an ideal neurophysiological toolExpand
Prevalence of mismatch negativity with tonal stimuli in normal-hearing individuals
Electrophysiological measures are one of the objective modes of assessment to check the integrity of the auditory function. The endogenous potentials like mismatch negativity (MMN) are responsesExpand
The Mismatch Negativity Where Is the Big Fish
In the present article, I will selectively review some of the recent research on the brain substrates of central-auditory processing using the mismatch negativity (MMN) and itsExpand
Memory-based or afferent processes in mismatch negativity (MMN): a review of the evidence.
TLDR
It is shown that the MMN cannot be accounted for by differential activation of the afferent N1 transient detectors by repetitive ("standard" stimuli and deviant ("novel") stimuli and that the presence of a memory representation of the standard is required for the elicitation of MMN. Expand
Erratum to: The Mechanisms and Meaning of the Mismatch Negativity
The mismatch negativity (MMN) is a pre-attentive auditory event-related potential (ERP) component that is elicited by a change in a repetitive acoustic pattern. It is obtained by subtractingExpand
Separation of mismatch negativity and the N1 wave in the auditory cortex of the cat: a topographic study
TLDR
The amplitude distribution of the frequency mismatch negativity (MMN) and that of P1 and N1 components were investigated in cats to reveal their sources in the auditory areas of the neocortex, finding the MMN is generated in the rostroventral part of the secondary auditory area. Expand
An fMRI Study of Impairments to Speech Perception in Patients with Vascular Sensory Aphasia
The aim of the present work was to use the noninvasive fMRI method to identify neurophysiological correlates of impairments at the sensory stage of the perception of verbal information, i.e.,Expand
Mismatch Negativity in Children with Cochlear Implant
TLDR
Values of latency, amplitude and area of MMN of children using cochlear implants were similar to those of hearing children, and did not differ between groups, and the occurrence ofMMN was not correlated to the variables of hearing, language and family categories. Expand
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References

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Practical Issues in the Clinical Application of Mismatch Negativity
TLDR
The mismatch negativity (MMN) recordings provide an objective measure of the preattentive, automatic auditory discrimination function and the interpretation of the results for clinical and electrodiagnostic purposes is discussed. Expand
Cerebral Generators of Mismatch Negativity (MMN) and Its Magnetic Counterpart (MMNm) Elicited by Sound Changes
  • K. Alho
  • Psychology, Medicine
  • Ear and hearing
  • 1995
TLDR
Results from studies aimed at localizing cerebral generators of MMN indicate that a major MMN source is located in the auditory cortex, and intracranial MMN recordings in animals suggest that at least in some species, MMN subcomponents also may be generated in the thalamus and hippocampus. Expand
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TLDR
A recently designed monitoring system is introduced, aimed at the continuous recording of late auditory potentials (N100 and MMN) as well as BAEPs and MLAEPs. Expand
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TLDR
In the present conditions of very strongly focused attention, the mismatch negativity component of the auditory event-related potential was elicited even by frequency change in the ignored input stream, and its amplitude was very similar to that of the MMN elicited by equivalent deviant stimuli (targets) in the attended input stream. Expand
The perception of speech sounds by the human brain as reflected by the mismatch negativity (MMN) and its magnetic equivalent (MMNm).
TLDR
MMN data indicate that each sound, both speech and nonspeech, develops its neural representation corresponding to the percept of this sound in the neurophysiological substrate of auditory sensory memory, and reveal the existence of such neuronal populations in the human brain that can encode acoustic invariances specific to each speech sound. Expand
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TLDR
Auditory event-related potentials and especially the mismatch negativity component (MMN) were examined in dysphasic and normal children and a negative correlation between the peak latency of the frequency MMN and age was found. Expand
Low dose of ethanol suppresses mismatch negativity of auditory event-related potentials.
TLDR
The novel finding of the significant (> 60% reduction in amplitude) suppression of the MMN can be interpreted as indicating disturbed preconscious detection of acoustic changes outside the scope of attention, which may be related to increased risk for accidents after alcohol ingestion. Expand
Separate Time Behaviors of the Temporal and Frontal Mismatch Negativity Sources
TLDR
The results support the hypothesis that the frontal MMN generator is activated later than the auditory cortex generator. Expand
The effects of channel-selective attention on the mismatch negativity wave elicited by deviant tones.
TLDR
Findings call into question the assertion that the auditory mismatch detection process and the associated MMN wave are wholly independent of attentional influence and provide evidence that the processing of stimuli in unattended channels can be attenuated or gated at an early sensory level under conditions of highly focused auditory selective attention. Expand
The MMN amplitude increases in hypnosis: a case study.
TLDR
The results indicate that hypnosis can give rise to altered information processing in the brain even at a relatively early, i.e. preattentive level and that the larger MMN measured under hypnosis does not support frontal inhibition theory. Expand
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