Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells

@inproceedings{Chen2012MislocalizationOD,
  title={Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells},
  author={Junjie Chen and H.-C. Jennifer Shen and Leslie A. Rivera Rosado and Yaqin Zhang and Xu Di and Baolin Zhang},
  booktitle={Oncotarget},
  year={2012}
}
Multiple clinical trials are ongoing to evaluate the potential antitumor activity of human TNF variants, Fas ligand (FasL), TNF-related apoptosis inducing ligand (TRAIL) and its agonistic antibodies. These drug products act through the death receptors (DRs) TNF receptor 1 (TNFR1), Fas/CD95, DR4 (TRAIL-R1) and/or DR5 (TRAIL-R2), respectively. Therefore… CONTINUE READING