Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation.

@article{Robbins2008MisinterpretingTT,
  title={Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation.},
  author={Marjorie A Robbins and Adam D. Judge and Ellen G. Ambegia and Catherine J Choi and Ed Yaworski and Lorne R. Palmer and Kevin D McClintock and Ian Maclachlan},
  journal={Human gene therapy},
  year={2008},
  volume={19 10},
  pages={991-9}
}
Activation of innate immunity has direct effects in modulating viral replication, tumor growth, angiogenesis, and inflammatory and other immunological processes. It is now established that unmodified siRNA can activate this innate immune response and therefore there is real potential for siRNA to elicit nonspecific therapeutic effects in a wide range of disease models. Here we demonstrate that in a murine model of influenza infection, the antiviral activity of siRNA is due primarily to immune… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 33 references

Inhibition of influenza virus production in virus-infected mice by RNA interference.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 12 Excerpts
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