Misfolding diverts CFTR from recycling to degradation

  title={Misfolding diverts CFTR from recycling to degradation},
  author={Manu Sharma and Francesca Pampinella and Csilla Nemes and Mohamed Benharouga and Jeffrey So and Kai Du and Kristi G Bache and Blake Papsin and Noa Zerangue and Harald Stenmark and Gergely L Lukacs},
  journal={The Journal of Cell Biology},
  pages={923 - 933}
To investigate the degradation mechanism of misfolded membrane proteins from the cell surface, we used mutant cystic fibrosis transmembrane conductance regulators (CFTRs) exhibiting conformational defects in post-Golgi compartments. Here, we show that the folding state of CFTR determines the post-endocytic trafficking of the channel. Although native CFTR recycled from early endosomes back to the cell surface, misfolding prevented recycling and facilitated lysosomal targeting by promoting the… CONTINUE READING

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