Misfolded proteins driven to destruction by Hul5

@article{Finley2011MisfoldedPD,
  title={Misfolded proteins driven to destruction by Hul5},
  author={Daniel Daniel Finley},
  journal={Nature Cell Biology},
  year={2011},
  volume={13},
  pages={1290-1292}
}
Misfolded proteins are potentially toxic and are therefore subjected to highly selective degradation by the ubiquitin–proteasome system. The identification of the Hul5 ubiquitin ligase as a major mediator of such 'quality-control' ubiquitylation following heat shock raises new questions about the design of these pathways.