Misfolded proteins driven to destruction by Hul5

  title={Misfolded proteins driven to destruction by Hul5},
  author={Daniel Daniel Finley},
  journal={Nature Cell Biology},
Misfolded proteins are potentially toxic and are therefore subjected to highly selective degradation by the ubiquitin–proteasome system. The identification of the Hul5 ubiquitin ligase as a major mediator of such 'quality-control' ubiquitylation following heat shock raises new questions about the design of these pathways.