Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.

@article{Ryu2007MisexpressionOP,
  title={Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.},
  author={Elizabeth J Ryu and James Wang and Nam Le and Robert H Baloh and Jason A. Gustin and Robert E. Schmidt and Jeffrey D. Milbrandt},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 43},
  pages={11552-9}
}
Pou3f1/SCIP/Oct-6 is a POU-domain transcription factor that is an important regulator of peripheral nerve myelination by Schwann cells. Pou3f1-deficient mice experience a developmental delay in myelination indicating that transient induction of Pou3f1 is required for normal development of peripheral myelin. The mechanism by which Pou3f1 regulates myelination is unclear, because it can both increase expression of Egr2, a transcription factor that promotes the myelination program, and also… CONTINUE READING
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