Misery perfusion with preserved vascular reactivity in Alzheimer's disease.

@article{Nagata1997MiseryPW,
  title={Misery perfusion with preserved vascular reactivity in Alzheimer's disease.},
  author={Ken Nagata and Robert J. Buchan and Eriko Yokoyama and Yasushi Kondoh and Mika Sato and Hiroo Terashi and Yuichi Satoh and Yasuhito Watahiki and M Senova and Yukimasa Hirata and Jun Hatazawa},
  journal={Annals of the New York Academy of Sciences},
  year={1997},
  volume={826},
  pages={272-81}
}
To elucidate the hemodynamic pathophysiology underlying Alzheimer's disease (AD), cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2) and oxygen extraction fraction (OEF) were measured with positron emission tomography in 10 patients with probable AD and in 20 age-matched normal volunteers. By the 15O intravenous bolus injection method, CBF was measured during resting state, CO2 inhalation (hypercapnia) and hyperventilation (hypocapnia), and the vascular reactivity (VR) was… CONTINUE READING