Miscoding properties of 8-chloro-2'-deoxyguanosine, a hypochlorous acid-induced DNA adduct, catalysed by human DNA polymerases.

@article{Sassa2013MiscodingPO,
  title={Miscoding properties of 8-chloro-2'-deoxyguanosine, a hypochlorous acid-induced DNA adduct, catalysed by human DNA polymerases.},
  author={A Shigeru Sassa and Nagisa Kamoshita and Tomonari Matsuda and Yuji Ishii and Isao Kuraoka and Takehiko Nohmi and Toshihiro Ohta and Masamitsu Honma and Manabu Yasui},
  journal={Mutagenesis},
  year={2013},
  volume={28 1},
  pages={81-8}
}
Many chronic inflammatory conditions are associated with an increased risk of cancer development. At the site of inflammation, cellular DNA is damaged by hypochlorous acid (HOCl), a potent oxidant generated by myeloperoxidase. 8-Chloro-2'-deoxyguanosine (8-Cl-dG) is a major DNA adduct formed by HOCl and has been detected from the liver DNA and urine of rats administered lipopolysaccharide in an inflammation model. Thus, the 8-Cl-dG lesion may be associated with the carcinogenesis of inflamed… CONTINUE READING

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The fully extended products were analysed to quantify the miscoding frequency and specificity of 8-Cl - dG using two - phased polyacrylamide gel electrophoresis ( PAGE ) .
The fully extended products were analysed to quantify the miscoding frequency and specificity of 8-Cl - dG using two - phased polyacrylamide gel electrophoresis ( PAGE ) .
At the site of inflammation , cellular DNA is damaged by hypochlorous acid ( HOCl ) , a potent oxidant generated by myeloperoxidase .
The fully extended products were analysed to quantify the miscoding frequency and specificity of 8-Cl - dG using two - phased polyacrylamide gel electrophoresis ( PAGE ) .
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