Miscibility phase diagrams of giant vesicles containing sphingomyelin.

@article{Veatch2005MiscibilityPD,
  title={Miscibility phase diagrams of giant vesicles containing sphingomyelin.},
  author={Sarah L. Veatch and Sarah L. Keller},
  journal={Physical review letters},
  year={2005},
  volume={94 14},
  pages={
          148101
        }
}
Saturated sphingomyelin (SM) lipids are implicated in lipid rafts in cell plasma membranes. Here we use fluorescence microscopy to observe coexisting liquid domains in vesicles containing SM, an unsaturated phosphatidylcholine lipid (either DOPC or POPC), and cholesterol. We note similar phase behavior in a model membrane mixture without SM (DOPC/DPPC/Chol), but find no micron-scale liquid domains in membranes of POPC/PSM/Chol. We delineate the onset of solid phases below the miscibility… 
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