Miscibility of octyl glucoside-phosphatidylcholine micellar solutions. Partition of the nicotinic acetylcholine receptor into the surfactant-rich phase.

Abstract

Phospholipid phosphatidylcholines (PC) and the nonionic detergent octyl glucoside (OG) were found to form a miscibility gap in aqueous solution at a molar ratio [OC]T/[PC]T=2.6-2.4. This ratio is just below the critical ratio for the formation of vesicles. At [PC] greater than 1.3 g/l the transition from micelles to vesicles is not direct but via a… (More)

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