• Corpus ID: 201783080

Miscibility of mixed monolayer of L-α-di-( cis-9-octadecenoic acid ) phosphatidylcholine and Rutin stearate at the air / water interface

@inproceedings{Duan2014MiscibilityOM,
  title={Miscibility of mixed monolayer of L-$\alpha$-di-( cis-9-octadecenoic acid ) phosphatidylcholine and Rutin stearate at the air / water interface},
  author={Yu Duan},
  year={2014}
}

• Yu Duan
• Published 2014
• Chemistry

The research on the miscibility of the mixed monola yer of unsaturated phosphatide and flavonoids can r eveal the mechanism of molecular interactions, which is impor tant for bioactive mechanism of action of flavonoid s. An amphiphilic rutin stearate (RS) was obtained by est erification of rutin with stearic acid catalyzed by immobilized Candida antarctica lipase B (Novozym 435), and the result suggested that the regioselectivity of the l ipase-catalyzed esterification of rutin was specific at the C 4’’’ position of the rhamnose moiety. The mixed monolay er of L-α-di-(cis-9-octadecenoic acid) phosphatidylcholine ( DOPC) and RS was spread at the air/water interface nd its miscibility at subphase temperatures of 37 °C and 10°C were investigated by Langmuir film balance. The tw o components of DOPC/RS mixed monolayer were miscible throughout the mixture composition range, and the better miscibility was obtained at higher subphase tempera ture, i.e., 37°C. At both subphase temperatures of 37 °C and 10 °C, the condensing effect of RS was most prominent at the lower surface pressure. The condensing effect could be ascribed to the match of RS and DOPC molecular shap es during the monolayer formation, and the molecule s of two components might occupy smaller areas.