Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila.

@article{Werz2005MisspecifiedCD,
  title={Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila.},
  author={Christian Werz and T Verne Lee and Peter L Lee and Melinda Lackey and Clare Bolduc and David S Stein and Andreas Bergmann},
  journal={Development},
  year={2005},
  volume={132 24},
  pages={5343-52}
}
Incorrectly specified or mis-specified cells often undergo cell death or are transformed to adopt a different cell fate during development. The underlying cause for this distinction is largely unknown. In many developmental mutants in Drosophila, large numbers of mis-specified cells die synchronously, providing a convenient model for analysis of this phenomenon. The maternal mutant bicoid is particularly useful model with which to address this issue because its mutant phenotype is a combination… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

ii REGULATION OF THE DROSOPHILA INITIATOR CASPASE DRONC THROUGH UBIQUITYLATION

HATEM ELIF KAMBER KAYA
2017
View 11 Excerpts
Highly Influenced

Cell death in development: Signaling pathways and core mechanisms.

Seminars in cell & developmental biology • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 73 references

Cellular degeneration in the production of some mutant phenotypes in Drosophila melanogaster

Molecular and General Genetics MGG • 1969
View 5 Excerpts
Highly Influenced

Analysis of genetic mosaics in developing and adult Drosophila tissues

S. Y. Yu, S. J. Yoo, +4 authors N. E. Baker
Development • 2002
View 4 Excerpts
Highly Influenced

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

C. Ghiglione, N. Perrimon, L. A. Perkins
J . Cell Biol • 1999
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…