Mirtazapine protects against cisplatin-induced oxidative stress and DNA damage in the rat brain.

@article{Gulec2013MirtazapinePA,
  title={Mirtazapine protects against cisplatin-induced oxidative stress and DNA damage in the rat brain.},
  author={Mustafa Gulec and Elif Varhan Oral and Onur Burak Dursun and Atakan Yucel and Ahmet Hacimuftuoglu and Fatih Akçay and Halis Suleyman},
  journal={Psychiatry and clinical neurosciences},
  year={2013},
  volume={67 1},
  pages={50-8}
}
AIM Cisplatin chemotherapy is associated with neurotoxicity, and oxidative stress might play an important role in the pathogenesis. Mirtazapine may be a preventative agent via its less-known antioxidant properties. The aim of this study was to examine the potential chemoprotective effects of mirtazapine against cisplatin-induced oxidative stress and DNA damage. METHODS Twenty-four rats were divided equally into four groups: control; cisplatin (10 mg/kg i.p.); cisplatin plus mirtazapine (10-30… CONTINUE READING