Mirtazapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation

@article{Nakayama2004MirtazapineID,
  title={Mirtazapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation},
  author={K. Nakayama and T. Sakurai and H. Katsu},
  journal={Brain Research Bulletin},
  year={2004},
  volume={63},
  pages={237-241}
}
Mirtazapine has a low affinity for 5-HT(1A) receptors but shows 5-HT(1A)-agonistic-like effects in behavioral pharmacology test. [...] Key Method In vivo microdialysis was used to study the effects of mirtazapine on extracellular dopamine and 5-HT levels, and the effect of the 5-HT(1A) antagonist WAY100,356 on extracellular dopamine level increased by mirtazapine in the rat prefrontal cortex. Mirtazapine (4-16 mg/kg, i.p.) produced a dose-dependent increase in extracellular dopamine levels in the medial…Expand
The effect of risperidone on the mirtazapine-induced changes in extracellular monoamines in the rat frontal cortex.
TLDR
The data indicate that the increase of cortical extracellular levels of DA and NA by combined administration of mirtazapine and risperidone may be of crucial importance to the pharmacotherapy of drug resistant depression, and that, among other mechanisms, 5-HT1A,5-HT2A, α2-adrenergic and histamine H1 receptors may play some role in this effect. Expand
A combination of mirtazapine and milnacipran augments the extracellular levels of monoamines in the rat brain
TLDR
Combined treatment with mirtazapine and milnacipran augments the extracellular levels of noradrenaline, serotonin and dopamine through the blockade of α(2) adrenoceptors without regional specificity, whereas mirtzapine enhances serotonergic transmission in a region-specific manner. Expand
Different actions for acute and chronic administration of mirtazapine on serotonergic transmission associated with raphe nuclei and their innervation cortical regions
TLDR
The results suggested that acute administration of mirtazapine probably activated serotonergic transmission, but its stimulatory action was abolished by activated inhibitory 5-HT1A receptor. Expand
Differential effects of adjunctive methylphenidate and citalopram on extracellular levels of serotonin, noradrenaline and dopamine in the rat brain
TLDR
The proposed augmentation effects of adjuvant methylphenidate to citalopram are most likely associated with enhanced dopamine transmission in the corticolimbic areas, whereas serotonin and noradrenaline levels show differential and region specific responses. Expand
Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies.
TLDR
Taking together, neurochemical approaches using microdialysis can not only contribute to clarification of the physiological role of the serotonergic neuronal systems but may also be a powerful pharmacological approach for the development of therapeutic strategies to the treatment of depression, schizophrenia, Parkinson's disease and drug abuse. Expand
Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation
TLDR
The concept that 5-HT(2A) receptors play a role in temperature regulation but that functional blockade of these receptors by mirtazapine is not a likely mechanism for restoring thermoregulatory processes in OVX rats is supported. Expand
Differential mechanisms underlie the regulation of serotonergic transmission in the dorsal and median raphe nuclei by mirtazapine: a dual probe microdialysis study
TLDR
The results suggest that enhanced serotonergic transmission resulting from α2 adrenoceptor blockade is offset by subsequent activation of 5-HT1A receptors and, in the DRN but not MRN, H1 receptor inhibition. Expand
Mirtazapine has a therapeutic potency in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of Parkinson’s disease
TLDR
Mirtazapine had a therapeutic potency against Parkinson’s disease in a mouse model and will be a useful drug for a future PD treatment. Expand
Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications
Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT) and dopamine (DA) interactions play a key role in normal and abnormal behavior. Therefore, disclosure of thisExpand
Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications.
TLDR
Electrophysiological and biochemical data are presented showing that endogenous 5-HT and pharmacological5-HT ligands modify the mesencephalic DA systems' activity and the functional interaction between the two monoamines will be discussed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission
  • T. de Boer
  • Medicine
  • International clinical psychopharmacology
  • 1995
TLDR
Mirtazapine can be described as a noradrenergic and specific serotonergic antidepressant (NaSSA), which prevents development of the side effects associated with non-selective 5-HT activation and may contribute to the anxiolytic and sleep-improving properties of this new compound. Expand
Ipsapirone enhances the dopamine outflow via 5-HT1A receptors in the rat prefrontal cortex.
TLDR
5-HT1A receptor agonists may be involved in the regulation of dopamine neurotransmission in the rat prefrontal cortex and may have therapeutic potential in the treatment of disorders associated with dysfunction of the mesocortical dopaminergic system. Expand
The pharmacologic profile of mirtazapine.
  • T. de Boer
  • Medicine
  • The Journal of clinical psychiatry
  • 1996
TLDR
Blockade of 5-HT2 and5-HT3 receptors possibly prevents side effects associated with nonselective 5- HT activation and may also contribute to the anxiolytic and sleep-improving properties of mirtazapine. Expand
Indirect in vivo 5-HT1A-agonistic effects of the new antidepressant mirtazapine
TLDR
It can be concluded that mirtazapine has indirect 5-HT1A receptor agonistic properties which may play an important role in the therapeutic effect of this compound. Expand
Noradrenergic modulation of central serotonergic neurotransmission: acute and long-term actions of mirtazapine
TLDR
Long-term treatment with mirtazapine showed that this tonic activation of postsynaptic 5-HT receptors was most likely enhanced after such a treatment, as a result of a sustained increase in 5- HT neuronal activity in the presence of and due to inactivated α2-adrenergic heteroreceptors. Expand
Effects of idazoxan on dopamine release in the prefrontal cortex of freely moving rats.
TLDR
The results suggest that the excessive dopaminergic neuronal activity in the rat prefrontal cortex is related to idazoxan-induced anxiogenic effects, and indicate that intact serotonergic neurons are required for the facilitatory effects of idaz Oxan on dopamine release. Expand
Serotonin 5-HT1A receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex
TLDR
The results indicate that drugs operating via 5-HT1A receptors in the cingulate cortex might control from this level the release of glutamate in the subcortical structures and may constitute an important target for drugs used to repair dysfunction of glutamate neurotransmission, which is observed for example in schizophrenia. Expand
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of α2‐adrenergic and serotonin2C receptors: a comparison with citalopram
TLDR
In contrast to citalopram, mirtazapine reinforces frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission, and reflects antagonist properties at α2A‐AR and 5‐HT2C receptors. Expand
Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo.
TLDR
Electrophysiological techniques were used to study the effects of various serotonin (5-HT) agonists and antagonists on the activity of dopamine (DA) neurons in the ventral tegmental area of rats and the effect of mCPP was more pronounced compared to that of TFMPP (maximal inhibition, 25%). Expand
Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo
TLDR
The data suggest that 5-HT2C receptors exert a tonic, inhibitory influence upon frontocortical dopaminergic and adrenergic, but not serotonergic, transmission. Expand
...
1
2
3
4
...