Mirtazapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation.

@article{Nakayama2004MirtazapineID,
  title={Mirtazapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation.},
  author={Kazuhiko Nakayama and Takashi Sakurai and Hisatoshi Katsu},
  journal={Brain research bulletin},
  year={2004},
  volume={63 3},
  pages={
          237-41
        }
}
Mirtazapine has a low affinity for 5-HT(1A) receptors but shows 5-HT(1A)-agonistic-like effects in behavioral pharmacology test. However, there is to date no clear evidence that mirtazapine enhances 5-HT(1A) neurotransmission. The object of the present study was to assess the effects of mirtazapine on dialysate levels of dopamine and 5-HT in the medial frontal cortex of freely moving rats and to determine whether this drug could modulate 5-HT(1A) neurotransmission. In vivo microdialysis was… CONTINUE READING
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