Mirtazapine enantiomers in blood and cerebrospinal fluid.

  title={Mirtazapine enantiomers in blood and cerebrospinal fluid.},
  author={Pierre Baumann and Mich{\`e}le Jonzier-Perey and Erik Paus and Georg Nikisch},
  volume={54 3},
Little information exists on the concentrations of recent antidepressants and their metabolites in cerebrospinal fluid (CSF). Using a stereoselective method, we measured plasma and CSF levels of mirtazapine (MIR), N-demethylmirtazapine and 8-OH-MIR in 3 depressed patients treated with racemic MIR (45 mg/day) for 4 weeks. S-(+)-MIR is considered to be the antidepressant enantiomer, but only R-(-)-MIR reached measurable concentrations in CSF. For R-(-)-MIR, the CSF/plasma ratio varied between 0… CONTINUE READING