Mirtazapine: An Antidepressant with Noradrenergic and Specific Serotonergic Effects

@article{Stimmel1997MirtazapineAA,
  title={Mirtazapine: An Antidepressant with Noradrenergic and Specific Serotonergic Effects},
  author={G. Stimmel and J. Dopheide and S. Stahl},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1997},
  volume={17}
}
Mirtazapine is a unique antidepressant that refines the specificity of effects on noradrenergic and serotonergic systems. It is an antagonist of presynaptic α2‐adrenergic autoreceptors and heteroreceptors on both norepinephrine and serotonin (5‐HT) presynaptic axons, plus is a potent antagonist of postsynaptic 5‐HT2 and 5‐HT3 receptors. The net outcome of these effects is increased noradrenergic activity together with specific increased serotonergic activity, especially at 5‐HT1A receptors… Expand
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