Mirror-Image Thymidine Discriminates against Incorporation of Deoxyribonucleotide Triphosphate into DNA and Repairs Itself by DNA Polymerases.

@article{Xiao2017MirrorImageTD,
  title={Mirror-Image Thymidine Discriminates against Incorporation of Deoxyribonucleotide Triphosphate into DNA and Repairs Itself by DNA Polymerases.},
  author={Yating Xiao and Qingju Liu and Xinjing Tang and Zhenjun Yang and Li Wu and Yujian He},
  journal={Bioconjugate chemistry},
  year={2017},
  volume={28 8},
  pages={
          2125-2134
        }
}
DNA polymerases are known to recognize preferably d-nucleotides over l-nucleotides during DNA synthesis. Here, we report that several general DNA polymerases catalyze polymerization reactions of nucleotides directed by the DNA template containing an l-thymidine (l-T). The results display that the 5'-3' primer extension of natural nucleotides get to the end at chiral modification site with Taq and Phanta Max DNA polymerases, but the primer extension proceeds to the end of the template catalyzed… CONTINUE READING
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