Mirasol PRT treatment of donor white blood cells prevents the development of xenogeneic graft-versus-host disease in Rag2-/-gamma c-/- double knockout mice.

@article{Fast2006MirasolPT,
  title={Mirasol PRT treatment of donor white blood cells prevents the development of xenogeneic graft-versus-host disease in Rag2-/-gamma c-/- double knockout mice.},
  author={Loren D Fast and Gilbert Dileone and Gene A. Cardarelli and Junzhi Li and Raymond P Goodrich},
  journal={Transfusion},
  year={2006},
  volume={46 9},
  pages={
          1553-60
        }
}
BACKGROUND Mirasol PRT (Navigant Biotechnologies) treatment utilizes exposure to light in the presence of riboflavin to introduce irreparable lesions to nucleic acids thereby inhibiting pathogen and WBC replication. The ability of Mirasol PRT-treated mononuclear cells (MNCs) to generate xenogeneic graft-versus-host disease (GVHD) responses was used to model transfusion-associated GVHD (TAGVHD). STUDY DESIGN AND METHODS Pairs of human MNCs from five different individual donors that had or had… CONTINUE READING
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