Mirabamides A-D, depsipeptides from the sponge Siliquariaspongia mirabilis that inhibit HIV-1 fusion.

@article{Plaza2007MirabamidesAD,
  title={Mirabamides A-D, depsipeptides from the sponge Siliquariaspongia mirabilis that inhibit HIV-1 fusion.},
  author={A. Plaza and E. Gustchina and Heather L. Baker and M. Kelly and C. Bewley},
  journal={Journal of natural products},
  year={2007},
  volume={70 11},
  pages={
          1753-60
        }
}
Four new cyclic depsipeptides termed mirabamides A-D (1-4) have been isolated from the marine sponge Siliquariaspongia mirabilis and shown to potently inhibit HIV-1 fusion. Their structures were elucidated by NMR and ESIMS, and absolute stereochemistry of the amino acids was determined using advanced Marfey's methods and NMR. Mirabamides contain two new entities, including 4-chlorohomoproline in 1-3 and an unusual glycosylated amino acid, beta-methoxytyrosine 4'-O-alpha-L-rhamnopyranoside (in 1… Expand
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Papuamides A−D (1−4) are also the first marine-derived peptides reported to contain 3-hydroxyleucine and homoproline residues, and contain a previously undescribed 2,3-dihydroxy-2,6,8-trimethyldeca-(4Z,6E)-dienoic acid moiety N-linked to a terminal glycine residue. Expand
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Hassallidin A, a new antifungal glycosylated lipopeptide, was isolated from an epilithic cyanobacterium collected in Bellano, Italy, identified as Tolypothrix (basionym Hassallia) species and contains both a fatty acid and a carbohydrate moiety. Expand
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TLDR
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Theonegramide (2) is an antifungal glycopeptide consisting of arabinose joined to a bicyclic dodecapeptide that contains the unusual amino acids β-hydroxyasparagine, isoserine, α-aminoadipic acid,Expand
Complete stereochemistry of neamphamide A and absolute configuration of the beta-methoxytyrosine residue in papuamide B.
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Theopalauamide, a Bicyclic Glycopeptide from Filamentous Bacterial Symbionts of the Lithistid Sponge Theonella swinhoei from Palau and Mozambique
Theopalauamide (1) is the major bicyclic peptide from the symbiotic filamentous eubacteria that are found in the interior of Theonella swinhoei from Palau. It was also isolated from T. swinhoei fromExpand
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