Mir-34a Is Upregulated during Liver Regeneration in Rats and Is Associated with the Suppression of Hepatocyte Proliferation

@inproceedings{Chen2011Mir34aIU,
  title={Mir-34a Is Upregulated during Liver Regeneration in Rats and Is Associated with the Suppression of Hepatocyte Proliferation},
  author={Huan Chen and Yimin Sun and Ruiqi Dong and Shengsheng Yang and Chuanyong Pan and Dao Xiang and Mingyong Miao and Bing-hua Jiao},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND MicroRNAs are a class of small regulatory RNAs that modulate a variety of biological processes, including cellular differentiation, apoptosis, metabolism and proliferation. This study aims to explore the effect of miR-34a in hepatocyte proliferation and its potential role in liver regeneration termination. METHODOLOGY/PRINCIPAL FINDING MiR-34a was highly induced after partial hepatectomy. Overexpression of miR-34a in BRL-3A cells could significantly inhibit cell proliferation and… CONTINUE READING