Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects.

@article{Medeiros2011Mir290295DI,
  title={Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects.},
  author={Lea A. Medeiros and Lucas Dennis and Mark Gill and Hristo Botev Houbaviy and Styliani Markoulaki and Dongdong Fu and Amy C Seila White and Oktay Kirak and Phillip A. Sharp and David C Page and Rudolf Jaenisch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 34},
  pages={14163-8}
}
Mir-290 through mir-295 (mir-290-295) is a mammalian-specific microRNA (miRNA) cluster that, in mice, is expressed specifically in early embryos and embryonic germ cells. Here, we show that mir-290-295 plays important roles in embryonic development as indicated by the partially penetrant lethality of mutant embryos. In addition, we show that in surviving mir-290-295-deficient embryos, female but not male fertility is compromised. This impairment in fertility arises from a defect in migrating… CONTINUE READING
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