Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells.

@article{Juan2009Mir214dependentRO,
  title={Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells.},
  author={A. Holgado-Terriza Juan and R. M. Satheesh Kumar and Joseph G Marx and Richard A. Young and Vittorio Sartorelli},
  journal={Molecular cell},
  year={2009},
  volume={36 1},
  pages={
          61-74
        }
}
Polycomb group (PcG) proteins exert essential functions in the most disparate biological processes. The contribution of PcG proteins to cell commitment and differentiation relates to their ability to repress transcription of developmental regulators in embryonic stem (ES) cells and in committed cell lineages, including skeletal muscle cells (SMC). PcG proteins are preferentially removed from transcribed regions, but the underlying mechanisms remain unclear. Here, PcG proteins are found to… CONTINUE READING
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