Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila.

@article{Sassu2012MiodChREBPCI,
  title={Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila.},
  author={Eric D. Sassu and Jacqueline E McDermott and Brendan J Keys and Melody Esmaeili and Alex C Keene and Morris J Birnbaum and Justin R Diangelo},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={426 1},
  pages={43-8}
}
During nutrient excess, triglycerides are synthesized and stored to provide energy during times of famine. The presence of high glucose leads to the activation of carbohydrate response element binding protein (ChREBP), a transcription factor that induces the expression of a number of glycolytic and lipogenic enzymes. ChREBP is expressed in major metabolic tissues and while we have a basic understanding of ChREBP function in liver, in vivo genetic systems to study the function of ChREBP in other… CONTINUE READING
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