Minute quantities of granulocyte-macrophage colony-stimulating factor prolong eosinophil survival.

@article{Esnault2001MinuteQO,
  title={Minute quantities of granulocyte-macrophage colony-stimulating factor prolong eosinophil survival.},
  author={Stephane Esnault and James S Malter},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2001},
  volume={21 2},
  pages={117-24}
}
Allergic asthma is characterized by pulmonary infiltration and accumulation of eosinophils, which is enhanced by granulocyte-macrophage colony-stimulating factor (GM-CSF). T cells, fibroblasts, and eosinophils themselves produce GM-CSF, suggesting it functions in the lung microenvironment as a survival factor. However, the amounts and the mechanism by which GM-CSF supports eosinophil survival remain poorly understood. We have previously reported that human peripheral blood eosinophils (PBEo… CONTINUE READING
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