Minute quantities of a single immunodominant foreign epitope are presented as large nested sets by major histocompatibility complex class II molecules.

@article{Vignali1993MinuteQO,
  title={Minute quantities of a single immunodominant foreign epitope are presented as large nested sets by major histocompatibility complex class II molecules.},
  author={Dario A A Vignali and Robert G. Urban and Roman M. Chicz and Jack Leonard Strominger},
  journal={European journal of immunology},
  year={1993},
  volume={23 7},
  pages={
          1602-7
        }
}
The processing and presentation of immunogenetic peptides is an obligate event in the generation of an immune response. However, the degree of complexity with which an immunogenic foreign epitope is presented is still unclear. This question was addressed by analyzing the naturally processed peptides generated from exogenously-derived hen egg white lysozyme (HEL) bound to the murine major histocompatibility complex (MHC) class II molecule, H-2Ak. Using reversed-phase chromatography (RPC), T cell… CONTINUE READING
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