Minute changes in composition of polymer substrates produce amplified differences in cell adhesion and motility via optimal ligand conditioning.


We explored the interplay between substratum chemistry of polymeric materials and surface-adsorbed ligand concentration (human plasma fibronectin) in the control of cell adhesion and cell motility. We found that small changes in the chemical composition of a polymeric substratum had different effects on cellular motility--depending on the concentration of… (More)


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