Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus

@inproceedings{Uematsu2016Mint3Apba3DA,
  title={Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus},
  author={Takayuki Uematsu and Tomoko Fujita and Hiroki J. Nakaoka and Toshiro Hara and Noritada Kobayashi and Yoshinori Murakami and Motoharu Seiki and Takeharu Sakamoto},
  booktitle={Scientific reports},
  year={2016}
}
Influenza virus (IFV) infection is a common cause of severe pneumonia. Studies have suggested that excessive activation of the host immune system including macrophages is responsible for the severe pathologies mediated by IFV infection. Here, we focused on the X11 protein family member Mint3/Apba3, known to promote ATP production via glycolysis by activating hypoxia inducible factor-1 (HIF-1) in macrophages, and examined its roles in lung pathogenesis and anti-viral defence upon IFV infection… CONTINUE READING
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