Minos as a genetic and genomic tool in Drosophila melanogaster.

@article{Metaxakis2005MinosAA,
  title={Minos as a genetic and genomic tool in Drosophila melanogaster.},
  author={Athanasios Metaxakis and Stefan Oehler and Apostolos Klinakis and Charalambos Savakis},
  journal={Genetics},
  year={2005},
  volume={171 2},
  pages={571-81}
}
Much of the information about the function of D. melanogaster genes has come from P-element mutagenesis. The major drawback of the P element, however, is its strong bias for insertion into some genes (hotspots) and against insertion into others (coldspots). Within genes, 5'-UTRs are preferential targets. For the successful completion of the Drosophila Genome Disruption Project, the use of transposon vectors other than P will be necessary. We examined here the suitability of the Minos element… CONTINUE READING
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